Objectives: We performed a scoping review of studies examining bupropion for treatment of methamphetamine dependence to provide a comprehensive overview of dosing regimens used, behavioral interventions provided in concert with bupropion therapy, and measures of effectiveness used in individuals seeking treatment for methamphetamine dependence.

Methods: The literature search was conducted by a librarian (T.M.) in Medline, Embase, CENTRAL, Cochrane Library, PsycINFO, and International Pharmaceutical Abstracts with no language filter, and a date limit from 1974 to present. Study selection was determined by two separate reviewers (K.V, P.L.), with any discrepancies resolved by a third reviewer (K.K.). EndNote was used to manage and remove duplicate citations. Data extraction was completed independently by two reviewers (K.V., K.K.) and then compiled to address the three main questions of the review.

Results: A total of 11 studies were included in our scoping review. Of the included studies, eight were randomized controlled trials. Additionally, a majority of the studies used extended release formulations of bupropion in various titration schedules, and there was heterogeneity between the studies in the types of behavioral therapy provided. With respect to the overall objective of this scoping review, in none of the studies was there discussion of integration of the behavioral therapy with the bupropion pharmacotherapy, either in the study design or in the results and discussion sections.

Conclusions: Future studies and clinical designs should consider different methods to integrate the dosing regimen with behavioral therapy to increase medication adherence and treatment efficacy.